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Brain Chemistry Treatment

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Neurotransmitter Testing

Although 100+ biomarkers are correlated and taken into account for each patient, we have decided to separate each treatment page based on the acquired educational delineations.  Moreover, you cannot address one bodily system without changing or relating to another one; thus, all treatment protocols are done in a unique holistic manner based on each patient’s 100+ biomarkers.  We cannot provide any treatment protocols due to legal restrictions, but concepts on each acquired abnormality can be discussed.  This page is dedicated to the concepts behind Brain Chemistry treatment.

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Although numerous neurotransmitters never cross the blood brain barrier (BBB), it was proven in 1959 that neurotransmitters, tested through urine analysis, are an adequate measurement of neurotransmitters. We were skeptical about using urine analysis as the basis for measurements of these biomarkers; however, through nearly 25,000 neurotransmitters assays, it was shown that these markers are changing significantly upon treatment and from patient to patient, which can be verified with results from the UCDTM protocol. Therefore, although many neurotransmitters do not cross the BBB, the urine analysis being performed does show improvement in the state of these chemicals when proper treatment is applied.

Many factors are considered in determining which biomarkers should be addressed; in this case what neurotransmitters should be evaluated, however, in the end it comes down to two primary factors.  The first focuses on the science, which means that extensive research is analyzed from the complex mechanisms of the biochemical reactions that take place in the brain amongst neurotransmitters. The cellular philosophy and cellular mechanisms outlined on the homepage are the basis for the direction of the aforementioned research. 

As the brain is not a solitary system, it’s no surprise that many co-factors are involved in the biochemical mechanisms in the brain. A co-factor is something that is required concurrently to make the reaction proceed.  For example, if you are studying a reaction where Compound A proceeds (converts) to Compound B, this reaction may require 1, 2, or many more different co-factors to proceed, [sometimes as many as 6 or 7 co-factors].  See this example below:

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In the above reaction where Compound A reacts to form Compound B, Compound C and D are co-factors for this reaction.  Thus, if you are trying to form Compound B by increasing Compound A, it is also vital to increase Compound C and D as well.  Otherwise, the reaction will not proceed effectively. After each mechanism and their involved co-factors were pinpointed for each reaction, then applied to each neurotransmitter, the second factor behind this approach was utilized.

The second primary factor involved in developing the treatment for Brain Chemistry is the patient.  You cannot solely treat every chemical that is high or low, in an attempt to manipulate each deficiency; therefore, the most safe and effective chemicals must be pinpointed. For example, GABA is an extremely difficult neurotransmitter to manipulate directly; therefore, GABA is manipulated by indirect mechanisms, by focusing on chemicals such as glutamate which is in balance with GABA.

Conversely, serotonin is a neurotransmitter that can be easily manipulated and is extremely safe and effective in relieving many symptoms and health issues.  However, many attempt to raise this chemical level without taking into account the science behind this reaction (see Western Diagnostics and Treatment for our viewpoint on SSRI anti-depressants). This reaction is shown below, however for simplification purposes, co-factors will not be shown.

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The above reactions are known as aromatic amino acid decarboxylase (only three of these reactions are shown for simplification). The main point is – this entire reaction is in equilibrium (which is what the double arrow denotes). This means if you make too much serotonin, you can risk plummeting dopamine and PEA. As PEA is primarily an excitatory neurotransmitter, this is the goal; however, you do not want to lower dopamine and run the risk of diminishing the PFC or NA (see Brain Chemistry page for more details).

It is like a scientific seesaw; everything is in balance. This is precisely what happens to many individuals who gain suicidal tendencies from prescription SSRI anti-depressants, because they ­raise serotonin, however their dopamine plummets. In these cases we say “raise” however SSRIs only recycle already existing serotonin and do not make any additional molecules of serotonin.

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Another common mistake by many physicians is they tend to focus on one part of the neurotransmitter system, such as the adrenals.  The adrenals are downstream and are not an underlying cause of the overall neurotransmitter system, let alone the brain and body.  Moreover, focusing on one part of one system does not allow us to gain an understanding of the larger picture.  We must understand how the brain and body function as a whole, not on an individual basis. Numerous neurotransmitters must be tested and correlated with other biomarkers in order to ascertain a proper viewpoint of how the brain and body is functioning.

The important lesson is to realize that by merely taking a supplement such as 5-HTP and expect to correct all related health issues, is not a realistic expectation.  Sometimes it's not even realistic to expect 5-HTP to raise serotonin alone. Other chemicals and neurotransmitters must be taken into account, not only in terms of the chemical you are focusing on, but the other reactions involved with said chemical.  Understand that this example [above] only covers raising serotonin and does not address any other chemicals and/or any corresponding co-factors; however, the concept of this serotonin example does provide the backbone of how we extrapolate this science and viewpoint to balance neurotransmitters as well as other related chemicals.

In conclusion – you must realize that the treatment of the brain and body is a complex science and the analysis of complex data from the results of a multitude of UCDTM testing must be done BEFORE developing a protocol to treat any abnormality. These protocols must be safe and effective for the patient while taking into account all the science on each reaction affected by the patient’s abnormality. These cellular philosophies and cellular mechanisms are the basis for all research including treatment of Brain Chemistry.

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